The series chronicles the adventures of a self-centered 13-year-old Thai-American girl named Anne Boonchuy. After stealing a mysterious treasure chest, she is magically transported to Amphibia, a wild marshland full of talking frog-people. She soon meets and befriends an adventurous young frog named Sprig Planter, who will guide her to be a true hero, while discovering the first true friendship of her life.